The innate immune response is the body’s first line of defense, involving fast, genetically programmed cellular reactions to potential environmental factors. This universal response naturally occurs across all organisms without the need for external activation. It engages specific types of white blood cells, such as neutrophils, monocytes, macrophages, and dendritic cells, which help maintain balance. Gamma-delta T-cells also contribute through a rapid response process facilitated by cytokines, including interferons.

Research has explored the role of polyprenyls, like those found in VetIMMUNE® PI, in supporting cellular functions. These compounds act as intracellular signals, contributing to the normal operations of immune cells like leukocytes (macrophages/monocytes, neutrophils) and gamma-delta T-cells. Additional studies have shown polyprenyls can influence cytokine expression in cell cultures, with preliminary findings in cats suggesting they may increase levels of interferons in blood leukocytes, indicating general immune activity.

Research from Harvard University has noted that polyprenyls contribute as signals in cellular processes and may provide antioxidative properties. Further studies suggest polyprenyls could support general liver health.